Small RNA sR158 Participates in Oxidation Stress Tolerance and Pathogenicity of Edwardaiella piscicida by Regulating TA System YefM-YoeB

In recent years, the role of bacterial sRNAs in adversity tolerance and pathogens has attracted increasing attention. A great number virulence-related were reported a variety human pathogens. However, only few from aquatic reported. our previous study, novel sRNA, sR158, was identified Edwardsiella piscicida, an important pathogen, but its function remains unknown. same we also type II TA system, YefM-YoeB, another study. current report, found that expression yefM-yoeB E. piscicida regulated by which is dependent on RNA chaperon Hfq. The deletion sR158 reduced to oxidation pressure, enhanced capacity for biofilm formation, increased adhesion invasion host cells immune tissues, boosted general virulence, are consistent with effects caused YefM-YoeB. These findings indicate participates stress resistance virulence regulating Our result first report system provides new insights into regulatory sRNA.